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Nasal air is used as a control intervention in clinical research to evaluate the therapeutic efficacy of supplemental oxygen. In a Phase II study sponsored by Region Skane, nasal air was administered at a flow rate of 3 liters per minute via nasal cannula to patients undergoing percutaneous coronary intervention (PCI) for stable angina or non-ST elevation myocardial infarction (NSTEMI). The study was designed to investigate whether the standard practice of providing supplemental oxygen actually provides superior ischemic pain relief compared to regular air, particularly since oxygen is known to cause coronary artery vasoconstriction and may lack benefit in patients with normal baseline oxygen saturation.
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