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Drug intelligence / Profile preview
Nasedyl Cough Linctus
- Development stage
- Unknown
- Lead developer
- National Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nasedyl Cough Linctus is an oral combination cough syrup developed and manufactured by National Pharmaceutical. It is approved in Hong Kong as an over-the-counter (OTC) western medicine for the relief of cough and associated respiratory symptoms. The formulation contains three active ingredients: codeine, ephedrine, and promethazine. Codeine acts as a centrally acting antitussive by agonizing the mu-opioid receptor to suppress the cough reflex. Ephedrine is a sympathomimetic amine that acts as an agonist on alpha- and beta-adrenergic receptors, providing bronchodilation and decongestant effects. Promethazine is a first-generation antihistamine that antagonizes histamine H1 receptors and muscarinic acetylcholine receptors, offering sedative, anti-allergic, and anticholinergic properties to alleviate runny nose and sneezing.
- Brand names
- Nasedyl Cough LinctusNasedyl Cough Linctus (Strong)
- Other names
- codeine + ephedrine + promethazine
02
Targets
ADRA1 (Alpha-1 adrenergic receptor family)ADRA2 (Adrenergic alpha-2 receptor family)ADRB1 (β1)MOR (Mu opioid receptor)mAChR (Muscarinic acetylcholine receptors)ADRA1A (α1A)ADRA2A (α2A)ADRB2 (β2)HRH1 (Histamine H1 Receptor)
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