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NAT-DP4 TK
- Development stage
- Preclinical
- Modality
- Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
NAT-DP4 TK is a T cell clone engineered to be specific for the HLA-DPB1*04:01/04:02 allele, which is a human leukocyte antigen (HLA) class II molecule. This clone was selected for its ability to produce high levels of interferon-gamma (IFNγ), tumor necrosis factor-alpha (TNFα), and interleukin-2 (IL-2) upon recognition of its target. The "TK" designation typically refers to the inclusion of a thymidine kinase suicide gene, which allows for selective elimination of the cells if needed, enhancing safety in adoptive cell therapy protocols. The primary application is in adoptive T cell therapy, where such engineered T cells are used to target specific antigens presented by HLA molecules on tumor or infected cells[7].
- Other names
- NAT-DP4[(TK)]
02
Targets
HLA-DPB1-peptide complex (Major histocompatibility complex, class II, DP beta 1 chain)
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