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National Inst. of Pharma Education and Research (NIPER) VEGFR-2 compound 8u

Development stage: Unknown
Lead developer: National Institute of Pharmaceutical Education and Research

Overview

National Inst. of Pharma Education and Research (NIPER) VEGFR-2 compound 8u: sourced facts only. name: "Further, VEGFR inhibition assay revealed that the compound 8u inhibited VEGFR-2 kinase with an IC50 of 1.52 ± 0.08 μM, comparable to the standard drug sunitinib (1.2 ± 0.07 μM)." [PMID:40712230]; target: "Further, VEGFR inhibition assay revealed that the compound 8u inhibited VEGFR-2 kinase with an IC50 of 1.52 ± 0.08 μM, comparable to the standard drug sunitinib (1.2 ± 0.07 μM)." [PMID:40712230]; developer: "Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India." [PMID:40712230]; stage: "Among the synthesized derivatives, compound 8u exhibited potent cytotoxicity against the HepG-2 cell line with an IC50 of 1.88 ± 0.83 μM." [PMID:40712230]

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)

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