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Natlean
- Development stage
- Preclinical
- Lead developer
- Metabolize
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Natlean (NATLEAN) is an oral, non-prescription dietary supplement (nutraceutical) developed by Metabolize, a consumer health startup founded in 2024. It is a synergistic formulation combining N-acetyltaurine, an appetite-signaling metabolite, and taurine in a single daily supplement. Natlean is designed to support appetite regulation (reducing 'food noise'), weight maintenance, and lean muscle, particularly for individuals transitioning off GLP-1 receptor agonist therapies. The underlying science, licensed exclusively from Stanford University, demonstrates that N-acetyltaurine suppresses food intake and body weight through a pathway that requires functional GDNF family receptor alpha-like (GFRAL) receptors in the brainstem, stimulating a GDF15-like endocrine response without affecting the brain's pleasure centers.
- Brand names
- NATLEAN
- Other names
- N-acetyltaurine + taurine
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