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natSc-DOTA-TATE
- Development stage
- Preclinical
- Lead developer
- Institute for Nuclear Chemistry and Technology
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
natSc-DOTA-TATE is a non-radioactive (cold) complex used as a reference standard in the development of scandium-based radiopharmaceuticals. It consists of natural scandium (natSc) chelated by DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and conjugated to the somatostatin analogue Tyr3-octreotate (TATE). This compound is primarily utilized in preclinical research to evaluate the binding affinity for somatostatin receptor subtype 2 (SSTR2), serving as a surrogate for the radioactive isotopes Scandium-44 (a PET imaging agent) and Scandium-47 (a therapeutic beta-emitter). By demonstrating high affinity for SSTR2, which is frequently overexpressed in neuroendocrine tumors, natSc-DOTA-TATE validates the targeting capability of the scandium-DOTA-peptide platform for theranostic applications.
- Other names
- natural scandium-DOTA-TATEnatSc-DOTATATESc-DOTA-TATE
02
Targets
SSTR2 (Somatostatin receptor type 2)
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