Drug intelligence / Profile preview

natural rubber latex allergen extract

Development stage: Unknown
Lead developer: Hospital Santiago Apostol
Modality: Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration: Sublingual

Overview

SLIT-Latex is a sublingual immunotherapy (SLIT) formulation containing natural rubber latex allergen extract derived from *Hevea brasiliensis*. It is designed to treat natural rubber latex (NRL) allergy by inducing immunological tolerance to latex proteins. The formulation is standardized by protein content (up to 500 mcg/mL) and contains human albumin, sodium chloride, phenol, and glycerine. It was evaluated in a randomized, double-blind, placebo-controlled clinical trial at the Hospital Santiago Apostol in Spain for patients suffering from latex-induced urticaria, angioedema, rhinitis, and asthma.

Brand names: SLIT-Latex
Other names: natural rubber latex (NRL) allergen extractHevea brasiliensis allergen extract

Targets

BCR-Hev-b (B-cell receptor specific for Hevea brasiliensis latex allergens)High-affinity immunoglobulin epsilon receptor-bound Immunoglobulin E complexHevea brasiliensis latex allergen proteinsT-cell receptor recognizing Hevea brasiliensis latex peptides

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