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Natureheme-iron is a heme-based iron dietary supplement evaluated by Chung Shan Medical University for its efficacy in improving iron absorption and antioxidant status in individuals with mild anemia. Unlike traditional inorganic iron supplements (such as ferrous sulfate), Natureheme-iron utilizes heme iron, which is absorbed via the heme carrier protein 1 (HCP1) in the intestinal mucosa. This pathway is more efficient and less prone to inhibition by dietary factors, potentially leading to better gastrointestinal tolerability. The supplement was studied in a randomized, double-blind, placebo-controlled trial (NCT02144311) at a dosage of 1000 mg (likely referring to the heme-iron complex) per day to assess its impact on hemoglobin levels, serum ferritin, and oxidative stress markers.
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