Drug intelligence / Profile preview

nauclea latifolia extract

Development stage
Unknown
Lead developer
National Institutes of Pharmaceutical R&D
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

*Nauclea latifolia* extract (derived from the African peach or *Sarcocephalus latifolius*) is a botanical extract traditionally used in West African ethnomedicine for the treatment of malaria, fever, pain, diabetes, and hypertension. A standardized aqueous root extract of the plant, developed under the code name NIPRD-AM1 by the National Institute for Pharmaceutical Research and Development (NIPRD) in Nigeria with support from the World Health Organization, has been clinically evaluated for the treatment of uncomplicated malaria. The extract contains bioactive indole alkaloids, such as strictosamide, which exhibit antiplasmodial activity against *Plasmodium falciparum*. Additionally, preclinical studies have investigated its potential anti-inflammatory, analgesic, and antidiabetic properties, as well as its in vitro cytotoxic activity against various cancer cell lines.

Other names
African peach extractNIPRD AM1Sarcocephalus latifolius extract
02

Targets

CYP3A4 (Cytochrome P450 3A4)

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