Drug intelligence / Profile preview

NB129

Development stage
Preclinical
Lead developer
Nanomerics
Modality
Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Intranasal
01

Overview

NB129 is a preclinical-stage intranasal nanoparticle powder formulation being developed by Nanomerics for the treatment of Parkinson's Disease. The drug utilizes Nanomerics' proprietary Molecular Envelope Technology (MET) to encapsulate a small molecule therapeutic within nanoparticles, which are then delivered using the Naltos delivery device. This single-use, disposable system uses inert gas to propel the nanoparticle powder through the nasal passages, facilitating nose-to-brain delivery via the olfactory and trigeminal nerve pathways. This approach is designed to bypass the blood-brain barrier and deliver the active pharmaceutical agent directly to the central nervous system, potentially addressing dopamine deficiencies associated with Parkinson's Disease while minimizing systemic side effects.

Brand names
Naltos Nasal Powder
Other names
Naltos

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