Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
NBM-BMX
- Development stage
- Phase 2
- Lead developer
- NatureWise Biotech & Medicals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
NBM-BMX is a selective small molecule inhibitor of histone deacetylase 8 (HDAC8) currently under development by NatureWise Biotech & Medicals. It is primarily being investigated for the treatment of glioblastoma multiforme (GBM), particularly in cases that have developed resistance to temozolomide (TMZ). The drug's mechanism involves the downregulation of the β-catenin/c-Myc/SOX2 signaling pathway and the upregulation of WT-p53 mediated MGMT inhibition, which collectively sensitizes resistant GBM cells to chemotherapy, inhibits cell proliferation, and triggers apoptosis. Clinical studies are evaluating its safety and efficacy as both a monotherapy and in combination with standard-of-care treatments like TMZ.
- Other names
- NBM BMX softgel capsulesNBM-BMX oral softgel capsules
02
Targets
HDAC8 (Histone Deacetylase 8)
Beyond the preview
Go deeper on NBM-BMX.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NBM-BMX.