NC-1900

NC-1900 is a synthetic hexapeptide analog of the arginine vasopressin (AVP) fragment AVP(4-9), developed by Nippon Chemiphar. It acts as a potent and selective agonist of the vasopressin V1A receptor. Designed for enhanced metabolic stability, NC-1900 possesses a half-life approximately five times longer than the endogenous AVP(4-9) fragment and demonstrates biological activity at significantly lower doses. The compound has been primarily investigated for its neuroprotective and cognitive-enhancing properties, showing efficacy in preclinical models of Alzheimer's disease (beta-amyloid-induced impairment), schizophrenia-related cognitive deficits (MK-801-induced), and scopolamine-induced memory impairment. Its development focuses on addressing nervous system disorders through the modulation of vasopressinergic pathways involved in learning and memory.

Other names

pGlu-Asn-Cys(Cys)-Pro-Arg-Gly-NH2L-Pyroglutamyl-L-asparaginyl-L-seryl-L-prolyl-L-arginylglycinamideAVP(4-9) analog