NC-6004 + gemcitabine

**NC-6004 + gemcitabine** is a combination chemotherapy comprised of NC-6004, a micellar nanoparticle formulation of cisplatin, and gemcitabine, a nucleoside analog. NC-6004 encapsulates cisplatin in a ~30 nm micellar nanoparticle designed to enable sustained release and selective tumor distribution, aiming to reduce dose-limiting toxicities (renal, neuro, oto) associated with traditional cisplatin, while maintaining antitumor efficacy[1][2][3]. Gemcitabine is a well-established cytotoxic agent. Preclinical and early-phase clinical studies indicate that combining NC-6004 and gemcitabine results in synergistic antitumor effects in multiple solid tumor models and cancer types, including pancreatic, lung, biliary tract, and bladder cancers[1][2][3]. The combination exhibits a toxicity profile similar to cisplatin-based regimens, but with reduced nephrotoxicity[1][2][3][4].

Brand names

NC-6004 + gemcitabine

Other names

nanoparticle cisplatin + gemcitabineNC-6004 combination therapyNC6004 combination therapyNC 6004 combination therapy