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NC-R17
- Development stage
- Unknown
- Lead developer
- Peking University
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
NC-R17: sourced facts only. name: "We also optimized the POI ligand of R17 with chloracetylamine replaced to propionamide to construct noncovalent GPX4 degrader NC-R17." [PMID:37098297]; target: "We also optimized the POI ligand of R17 with chloracetylamine replaced to propionamide to construct noncovalent GPX4 degrader NC-R17." [PMID:37098297]; developer: "State Key Laboratory of Natural and Biomimetic Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing, China." [PMID:37098297]; modality: "Such noncovalent modification led to a moderate GPX4 degradation activity and represents a promising strategy for the development of noncovalent GPX4 PROTACs." [PMID:37098297]
02
Targets
GPX4 (Glutathione peroxidase 4)
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