Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
NCC-1566
- Development stage
- Preclinical
- Lead developer
- Nissan Chemical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
NCC-1566 is a first-in-class, orally active, small molecule inwardly rectifying potassium channel (Kir) activator, specifically targeting Kir4.1 (KCNJ10) channels. Developed by Nissan Chemical Corporation, NCC-1566 is designed to restore potassium and glutamate homeostasis in astrocytes, thereby hyperpolarizing the resting membrane potential and reducing neuronal hyperexcitability. In preclinical rodent models, NCC-1566 has demonstrated potent anticonvulsant and antiepileptic activity, showing efficacy in models of acute seizure, mesial temporal lobe epilepsy (MTLE), amygdala kindling, and sudden unexpected death in epilepsy (SUDEP). Furthermore, NCC-1566 has shown synergistic potential when combined with levetiracetam in pharmacoresistant seizure models, suggesting its potential as an add-on therapy for refractory epilepsy.
- Other names
- NCC 1566NCC1566NCC-1566
Beyond the preview
Go deeper on NCC-1566.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NCC-1566.