NCL 00017509

**NCL 00017509** is a potent, kinase-selective, and generally described as either *irreversible* or *reversible* inhibitor of **NIMA related kinase 2 (Nek2)**, with an IC50 of 56 nM. The compound disrupts centrosome duplication and cell cycle progression by targeting the ATP-binding domain of Nek2, leading to increased mitotic abnormalities and mitotic delay. It is cell permeable and active in vivo, notably decreasing PD-L1 expression and inducing anticancer immunity in mouse models bearing pancreatic tumors. Its chemical structure is 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide, molecular formula C15H12N6O, and it is primarily used in research settings for probing Nek2 function and as a potential anticancer tool compound[1][3][4][5][7].

Other names

3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamideBenzeneacetamide, 3-[(6-ethynyl-9H-purin-2-yl)amino]-2-(3-((6-ethynyl-9H-purin-2-yl)amino)phenyl)acetamide