NCL-1

NCL-1 is a cell-permeable, selective, and irreversible small molecule inhibitor of lysine-specific histone demethylase 1A (LSD1/KDM1A). Developed as a chemical probe, it is used to investigate the epigenetic regulation of gene expression in various cancers. NCL-1 functions by increasing the levels of dimethylated histone H3 lysine 4 (H3K4me2) and H3 lysine 9 (H3K9me2), which leads to the activation of tumor suppressor genes and the downregulation of stemness markers. Preclinical studies have demonstrated its efficacy in reducing the proliferation and stemness of glioblastoma, glioma, breast cancer, and prostate cancer cells. It has also been shown to sensitize glioblastoma stem cells to endoplasmic reticulum (ER) stress inducers by activating the unfolded protein response (UPR).

Other names

NCL1NCL-1NCL 1N-((1S,2R)-2-phenylcyclopropyl)benzamide