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NCP07
- Development stage
- Unknown
- Lead developer
- Wuhan University
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
NCP07: sourced facts only. name: "Among them, compound NCP07 could potently degrade ERα and inhibited proliferation (IC50 = 0.13-1.22 μM) in both wild-type and ESR1-mutated cell lines." [PMID:42391931]; target: "Among them, compound NCP07 could potently degrade ERα and inhibited proliferation (IC50 = 0.13-1.22 μM) in both wild-type and ESR1-mutated cell lines." [PMID:42391931]; developer: "Department of Hematology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China; Department of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430071, China." [PMID:42391931]; modality: "we developed a class of novel and potent ERα PROTAC degraders against ET-resistant breast cancer." [PMID:42391931]
02
Targets
ESR1 (ERα)
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