Drug intelligence / Profile preview

ND-BT8226

Development stage
Preclinical
Lead developer
Eli Lilly
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Ligand-Fc Fusions → Fc Fusion Proteins → Engineered Antibody Formats → Antibody-Based Therapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

ND-BT8226 is an investigational drug candidate being developed through a research and collaboration agreement between **BioArctic** and **Eli Lilly**, announced in June 2026. The project utilizes BioArctic's proprietary **BrainTransporter** technology, which is designed to facilitate the active transport of biologics across the blood-brain barrier (BBB) by targeting the **transferrin receptor (TfR)**. In this collaboration, the BrainTransporter platform is combined with an undisclosed Eli Lilly proprietary molecule to address neurodegenerative diseases. Under the terms of the agreement, BioArctic received an upfront payment of $30 million and is eligible for up to $770 million in milestone payments, plus royalties. Eli Lilly is responsible for the global development and commercialization of the resulting drug candidate.

02

Targets

TFRC (Transferrin Receptor)

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