Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
NDV-f0-GFP
- Development stage
- Preclinical
- Lead developer
- Erasmus MC
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Intratumoral
01
Overview
NDV-f0-GFP is a recombinant, lentogenic (low-pathogenicity) strain of the Newcastle Disease Virus (NDV) engineered to express Green Fluorescent Protein (GFP) as a reporter gene. As an oncolytic virus, it selectively infects and replicates within tumor cells, such as glioblastoma, by exploiting deficiencies in the host cell's antiviral interferon signaling pathways. The "f0" designation refers to the fusion (F) protein, which is a critical determinant of viral entry and spread; in lentogenic strains, the F protein cleavage site is typically restricted to specific extracellular proteases, enhancing its safety profile. NDV-f0-GFP is being investigated for its ability to induce direct oncolysis and stimulate a systemic anti-tumor immune response through the release of cytokines and tumor-associated antigens.
- Other names
- Newcastle Disease Virus-f0-GFPlentogenic NDV-f0-GFP
02
Targets
Sia (Terminal cell-surface sialic acid residues on glycoconjugates)
Beyond the preview
Go deeper on NDV-f0-GFP.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NDV-f0-GFP.