nebivolol + lisinopril

Nebivolol + lisinopril is a fixed-dose combination of two antihypertensive agents used to treat high blood pressure (hypertension). Nebivolol is a highly selective beta-1 adrenergic receptor antagonist (beta-blocker) that lowers blood pressure by reducing heart rate, myocardial contractility, and peripheral vascular resistance. It also uniquely stimulates endothelial nitric oxide synthase via beta-3 agonism, leading to vasodilation. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that reduces the formation of angiotensin II, resulting in vasodilation and decreased aldosterone secretion. The combination provides additive or synergistic effects on lowering blood pressure compared to either agent alone, making it effective for patients with stage 2 hypertension who require more than one medication for adequate control[2][5][6]. Both drugs are approved for use in hypertension; lisinopril is also indicated for heart failure and post-myocardial infarction management[1].

Brand names

Bystolic + PrinivilBystolic + Zestril

Other names

nebivolol and lisinoprilbeta-blocker and ACE inhibitor combination