Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
nebulised alteplase
- Development stage
- Unknown
- Lead developer
- University College London
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Inhalation
01
Overview
Nebulised alteplase (recombinant tissue-plasminogen activator, rt-PA) is an investigational nebulised formulation of the thrombolytic enzyme alteplase. Developed by University College London (UCL), it is administered via inhalation directly into the lungs to target fibrin clots and microthrombi in the alveolar compartment. By converting plasminogen to plasmin, it facilitates localized thrombolysis, aiming to improve oxygenation and reduce alveolar clotting. This formulation was evaluated in the Phase II PACA (Plasminogen Activator COVID-19 ARDS) pilot trial for the treatment of patients with COVID-19-induced acute respiratory distress syndrome (ARDS).
- Other names
- nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 1nebulised recombinant tissue-plasminogen activatornebulised rt-PAnebulized alteplasenebulized recombinant tissue-plasminogen activatornebulized rt-PA
02
Targets
Fibrin (Factor Ia)PLG (Plasminogen)PAI-1 (Plasminogen activator inhibitor type 1)SERPINF2 (Alpha-2-antiplasmin)
Beyond the preview
Go deeper on nebulised alteplase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on nebulised alteplase.