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Drug intelligence / Profile preview
nefazodone
- Development stage
- Approved
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nefazodone is an antidepressant classified as a phenylpiperazine and serotonin modulator. It is primarily used to treat depression, including major depressive disorder. Its mechanism of action involves inhibiting the neuronal uptake of serotonin and norepinephrine, thereby increasing their levels in the brain. Additionally, nefazodone acts as an antagonist at central 5-hydroxytryptamine type 2 (5-HT2) receptors and alpha1-adrenergic receptors, which may contribute to its therapeutic effects and side effect profile. Unlike selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), or monoamine oxidase inhibitors (MAOIs), nefazodone has a distinct chemical structure and pharmacological profile[1][3][4][5]. The drug was originally developed by Bristol-Myers Squibb.
- Brand names
- SerzoneNefadar
- Other names
- NefazodonaNefazodonum
02
Targets
HTR2A (Serotonin receptor 5-HT2A)ADRA1A (α1A)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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