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neisseria meningitidis group B factor H binding protein subfamily B
- Development stage
- Unknown
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Neisseria meningitidis group B factor H binding protein subfamily B is a recombinant protein vaccine candidate developed by Assistance Publique - Hôpitaux de Paris (AP-HP) for the prevention of meningococcal group B infection. The vaccine consists of the subfamily B (also known as variant 1) of the factor H binding protein (fHbp), a surface lipoprotein that allows *Neisseria meningitidis* to evade the host's immune system by binding human factor H, a down-regulator of the alternative complement pathway. By inducing the production of antibodies that block this interaction, the vaccine facilitates complement-mediated bactericidal activity against the pathogen. It has been investigated in Phase 1 clinical trials to evaluate its safety and immunogenicity profile in healthy adults, typically formulated with an aluminum hydroxide adjuvant.
- Other names
- fHbp subfamily BfHbp variant 1recombinant Neisseria meningitidis group B factor H binding protein subfamily B
02
Targets
fHbp (Factor H-binding protein)CFH (Complement factor H)
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