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Neisseria meningitidis group C capsular polysaccharide tetanus toxoid conjugate antigen

Development stage
Approved
Lead developer
Sanofi
Modality
Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Neisseria meningitidis group C capsular polysaccharide tetanus toxoid conjugate antigen is a component of several quadrivalent and bivalent vaccines designed to prevent invasive disease caused by Neisseria meningitidis serogroup C. This vaccine antigen consists of the purified capsular polysaccharide from Neisseria meningitidis serogroup C covalently linked (conjugated) to tetanus toxoid protein. The conjugation enhances immunogenicity, especially in infants and young children, by inducing a T-cell dependent immune response that leads to long-lasting immunity and immunological memory. These vaccines are primarily indicated for active immunization against invasive meningococcal disease caused by Neisseria meningitidis serogroups including C[3][6][8]. Major products containing this antigen include MenQuadfi (Sanofi), Nimenrix (Pfizer), and Penbraya (Pfizer). The primary indication is prevention of invasive meningococcal disease.

Brand names
MenQuadfiNimenrixPenbraya
Other names
Nimenrix component neisseria meningitidis group C capsular polysaccharide tetanus toxoid conjugate antigen
02

Targets

TT (Tetanus toxoid)Neisseria meningitidis group C capsular polysaccharide

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