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Neixiao Luoli Pill is a traditional Chinese patent medicine (TCPM) formulated to "soften hardness and dissipate nodules," a therapeutic principle in Chinese medicine used to treat masses and swellings. It is composed of a complex mixture of herbal ingredients, typically including *Prunella vulgaris* (Xiaoku Cao), *Scrophularia ningpoensis* (Xuan Shen), *Sargassum* (Hai Zao), and *Rehmannia glutinosa* (Di Huang), among others. The pill is traditionally indicated for scrofula (cervical lymphadenitis), goiter, and other subcutaneous swellings. In modern clinical research, particularly in trials led by Zhejiang Provincial People's Hospital, it is being evaluated for its efficacy and safety in treating benign or low-risk thyroid nodules. The mechanism is thought to involve anti-inflammatory and anti-proliferative effects that promote the reduction of nodule size and improve ultrasound findings and related symptoms.
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