nelarabine

Nelarabine is a small molecule prodrug of the nucleotide metabolism inhibitor deoxyguanosine analogue 9-β-arabinoguanine (ARA-G). It is converted to its active form, ARA-GTP, through catalytic transformation by adenosine deaminase (ADA) and subsequent phosphorylation by deoxyguanosine kinase and deoxycytosine nucleoside kinase. ARA-GTP accumulates within leukemic blast cells, where it binds to deoxyribonucleic acid (DNA), effectively inhibiting DNA synthesis and ultimately leading to cell death. Nelarabine is a T-cell specific purine nucleoside analogue and is approved for the treatment of relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

Brand names

ArranonArranon GSH-111SH111SH 111

Other names

nelarabine injectionara-G9-β-arabinoguanine