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nelipepimut-s + sargramostim
- Development stage
- Phase 2
- Lead developer
- SELLAS Life Sciences Group
- Modality
- Peptide-based Cancer Vaccines → Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
Nelipepimut-S + sargramostim is a cancer vaccine consisting of the HER2-derived MHC class I peptide E75 (nelipepimut-S) combined with granulocyte-macrophage colony-stimulating factor (GM-CSF, sargramostim). The vaccine is designed to stimulate a specific cytotoxic T-lymphocyte response against HER2/neu-expressing tumor cells, particularly in breast cancer. Nelipepimut-S is an immunogenic peptide from the HER2 protein that is highly expressed in breast cancer, while sargramostim serves as an immune adjuvant to enhance the immune response.
- Brand names
- NeuVax
- Other names
- Nelipepimut-S plus GM-CSF vaccineE75 peptide vaccineE-75 peptide vaccineE 75 peptide vaccine
02
Targets
CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)HLA-A*03:01 (DARKFOX-A3 peptide-HLA-A*03:01 complex)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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