Drug intelligence / Profile preview

nelumbinis folium

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Nelumbinis folium refers specifically to the dried leaves of the lotus plant (Nelumbo nucifera), widely used in traditional Chinese medicine and other Asian medical systems. The leaves contain a variety of bioactive compounds including flavonoids (such as quercetin and catechin), alkaloids (like nuciferine and neferine), and other benzylisoquinoline alkaloids. These constituents are believed to contribute to its pharmacological effects. **Mechanism of Action:** The main mechanisms attributed to nelumbinis folium include antioxidant activity (scavenging free radicals), anti-inflammatory effects (inhibiting pro-inflammatory mediators such as TNF-α, IL-6, nitric oxide, prostaglandin E2), lipolytic action (promoting fat metabolism and reducing fat accumulation), diuretic effect (promoting urine excretion for detoxification and reducing edema), hypolipidemic effect (lowering blood lipid levels), hypoglycemic effect (regulating blood sugar levels) and antibacterial properties[1][2][3][4][5][6]. **Primary Indications:** Traditionally used for weight management/obesity, hyperlipidemia, cardiovascular health support, promoting urination/detoxification, clearing summer heat/fever reduction ("qing re jie shu"), supporting digestion/diarrhea relief, bleeding disorders due to its astringent properties[3][4]. It is also sometimes used cosmetically or in functional foods.

Other names
荷叶lotus leafHe YeNelumbo nucifera leaf
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)

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