nemadipine-A

Nemadipine-A is a dihydropyridine-class small molecule that acts as an L-type calcium channel antagonist. Originally identified in a chemical genetic screen in *Caenorhabditis elegans* for its ability to phenocopy mutations in the *egl-19* gene (encoding an L-type calcium channel subunit), it has been repurposed in oncology research. Nemadipine-A has been shown to modulate the epithelial-mesenchymal transition (EMT) by influencing the alternative splicing of FGFR2, specifically promoting the inclusion of the epithelial-specific exon IIIb over the mesenchymal-specific exon IIIc. In preclinical models of prostate cancer, intraperitoneal administration of nemadipine-A has been demonstrated to reduce cell migration and inhibit tumor growth in xenografts.