Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
NENF siRNA
- Development stage
- Preclinical
- Lead developer
- McGill University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
NENF siRNA is a small interfering RNA (siRNA) designed to silence the expression of the neuron-derived neurotrophic factor (NENF) gene. NENF has been identified as a candidate oncogene that is frequently activated by DNA hypomethylation in various malignancies, including hepatocellular carcinoma (HCC) and bladder cancer. By targeting NENF mRNA for degradation, this siRNA inhibits cancer cell viability, anchorage-independent growth, and invasive potential. Preclinical research indicates that NENF depletion modulates key oncogenic signaling pathways, specifically the PI3K/AKT and MAPK pathways, and may also influence the DNA methylation machinery by down-regulating DNMT1 and MBD2. The therapeutic relevance of NENF siRNA has been explored in various cancer cell lines, including HepG2, SkHep1, and T24.
- Other names
- siRNA targeting NENFNENF-siRNA
02
Targets
Neurotrophin (Neurotrophin ligand family)
Beyond the preview
Go deeper on NENF siRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NENF siRNA.