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neoadjuvant chemotherapy-Professor Fernando Figueira Integral Medicine Institute-ovarian cancer
- Development stage
- Phase 2
- Lead developer
- Instituto de Medicina Integral Professor Fernando Figueira
- Modality
- Small Molecules
- Administration
- Intravenous, Intraperitoneal
01
Overview
This refers to a specific clinical trial protocol (NCT02249013) developed by the Professor Fernando Figueira Integral Medicine Institute (IMIP) for the treatment of stage III-IV epithelial ovarian cancer with high tumor burden. The regimen consists of neoadjuvant chemotherapy (NACT) using carboplatin and paclitaxel, followed by interval debulking surgery (IDS) combined with short-course Hyperthermic Intraperitoneal Chemotherapy (HIPEC). The HIPEC component involves the administration of cisplatin (with or without doxorubicin) directly into the peritoneal cavity at temperatures of 41-43°C for 30 minutes. Following surgery, patients receive adjuvant chemotherapy with the same carboplatin and paclitaxel combination to complete a total of six systemic cycles. This multimodal approach aims to maximize cytoreduction and target residual microscopic disease through both systemic and localized delivery enhanced by hyperthermia.
- Other names
- Short-course HIPEC at Interval Debulking SurgeryIMIP HIPEC protocolShort-course Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) at Interval Debulking Surgery for High Tumor Burden Ovarian Cancer
02
Targets
DNATOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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