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Drug intelligence / Profile preview
neohesperidin dihydrochalcone
- Development stage
- Preclinical
- Lead developer
- Jeju National University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Neohesperidin dihydrochalcone (NHDC) is a semi-synthetic flavonoid sweetener derived from citrus fruits, primarily known for its intense sweetness and use as a food additive (E959). Beyond its application in the food industry, NHDC has emerged as a potential therapeutic agent due to its antioxidant and anti-inflammatory properties. Recent research, such as that presented at AACR 2026, identifies NHDC as a potent inhibitor of ferroptosis, a form of iron-dependent regulated cell death. It acts by targeting the System Xc− pathway, mitigating the accumulation of lipid reactive oxygen species (ROS) and modulating the expression of ferroptosis-related proteins like SLC7A11 and SLC3A2. This mechanism suggests potential applications in treating various ferroptosis-related pathologies, including cancer and neurodegenerative diseases.
- Other names
- Neohesperidin DCE959E-959E 959
02
Targets
PPA (Porcine pancreatic alpha-amylase)TAS1R2 (Taste receptor type 1 member 2)SLC3A2 (Solute carrier family 3 member 2)SLC7A11 (Cystine-Glutamate Antiporter)
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