neomycin + colistin + nystatin + vancomycin

This is a combination drug consisting of four active ingredients—neomycin, colistin, nystatin, and vancomycin. Each component has a distinct antimicrobial mechanism: - **Neomycin** is an aminoglycoside antibiotic that binds to bacterial ribosomes and inhibits protein synthesis, leading to bactericidal activity against a broad spectrum of gram-positive and gram-negative bacteria[1]. - **Colistin** (also known as polymyxin E) is a polymyxin antibiotic that disrupts the bacterial cell membrane of susceptible gram-negative organisms by acting as a cationic detergent[2]. - **Nystatin** is an antifungal agent that binds to ergosterol in fungal cell membranes, creating pores and causing leakage of cellular contents; it is primarily effective against Candida species[2]. - **Vancomycin** is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala termini in peptidoglycan precursors; it has potent activity against gram-positive bacteria including resistant strains such as MRSA[8]. This combination would provide broad-spectrum antibacterial (including multidrug-resistant organisms) and antifungal coverage. Such combinations are typically used for severe or mixed infections where both fungal and resistant bacterial pathogens are suspected or confirmed.

Other names

Simplified SDDSDD protocolNeomycin-Colistin-Nystatin-Vancomycin