Drug intelligence / Profile preview

neomycin + polymyxin B + bacitracin + hydrocortisone

Development stage
Approved
Lead developer
Glaxo Wellcome
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Topical, Ophthalmic
01

Overview

This drug is a **combination topical or ophthalmic medication** containing four active ingredients: neomycin, polymyxin B, bacitracin, and hydrocortisone. - **Neomycin, polymyxin B, and bacitracin** are antibiotics that act synergistically to inhibit bacterial growth by interfering with protein synthesis (neomycin), disrupting bacterial cell membrane integrity (polymyxin B), and inhibiting cell wall synthesis (bacitracin). - **Hydrocortisone** is a corticosteroid that reduces inflammation, redness, swelling, and itching by activating anti-inflammatory pathways. This combination is mainly indicated for treating or preventing **bacterial skin and eye infections** and also for controlling associated inflammation. It is supplied as ointment for ophthalmic use and for topical skin application[1][3][5][7][14].

Brand names
CortisporinNeo-Polycin HCNeotricin HC
Other names
neomycin/polymyxin B/bacitracin/hydrocortisone ophthalmicneomycin and polymyxin B sulfates/bacitracin zinc/hydrocortisone ointmentneomycin-bacitracin-polymyxin-hydrocortisone ointmentneomycin+polymyxin B+bacitracin+hydrocortisone topical ointmentbacitracin; hydrocortisone; neomycin; polymyxin B topical ointment
02

Targets

GR (Glucocorticoid receptor)C55-PP (Undecaprenyl pyrophosphate)Bacterial Ribosome

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