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Neomycin sulfate is an aminoglycoside antibiotic used in veterinary medicine for the treatment of intestinal infections. It is poorly absorbed from the gastrointestinal tract, making it highly effective for treating localized infections within the gut, such as bacterial enteritis caused by *Escherichia coli*, *Salmonella* spp., and other Gram-negative bacteria. It exerts its bactericidal effect by binding to the 30S subunit of the bacterial ribosome, leading to the misreading of mRNA and the inhibition of protein synthesis. The soluble powder formulation is typically administered to livestock, including poultry, swine, and cattle, through drinking water or milk replacers.
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