neomycin sulfate + polymyxin B sulfate + hydrocortisone + thonzonium bromide

This drug is a **combination otic suspension** containing four active ingredients: **neomycin sulfate** (an aminoglycoside antibiotic that inhibits bacterial protein synthesis), **polymyxin B sulfate** (a polypeptide antibiotic that disrupts bacterial cell membranes), **hydrocortisone** (a corticosteroid that suppresses inflammation by regulating gene expression and protein synthesis), and **thonzonium bromide** (a surface-active agent that promotes penetration by dispersing cellular debris and exudate). It is primarily indicated for the treatment of infections and inflammation of the external ear canal, especially where the risk of bacterial infection and inflammation coexist. This formulation is **non-viscous, buffered at acidic pH**, instilled directly into the affected ear canal[1][2].

Brand names

Cortisporin TC Otic