Drug intelligence / Profile preview

NeoSLP

Development stage
Phase 2
Lead developer
Jaime Leandro Foundation for Therapeutic Cancer Vaccines
Modality
Vaccines & Immunotherapeutics, Peptides
01

Overview

NeoSLP is a personalized neoantigen synthetic long peptide (SLP) vaccine developed by the Jaime Leandro Foundation for Therapeutic Cancer Vaccines for the treatment of solid tumors, including pancreatic adenocarcinoma and glioblastoma. The vaccine is a peptide-based immunotherapy that utilizes patient-specific synthetic long peptides designed based on whole exome sequencing and predictive algorithms to identify unique tumor mutations. These neoantigens are intended to stimulate the patient's T-cells to recognize and attack cancer cells. The vaccine is currently being evaluated in a Phase 1b/2 clinical trial and is also available through the FDA's Expanded Access program for compassionate use.

Other names
Personalized Synthetic Long Peptide VaccineNeoantigen Synthetic Long Peptide Vaccine
02

Targets

pMHC (Peptide-MHC complex family)Neoantigen-specific T-cell receptor

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