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NeoTCR-P201
- Development stage
- Unknown
- Lead developer
- PACT Pharma
- Modality
- TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
NeoTCR-P201 is a personalized, adoptive cell therapy consisting of autologous T cells engineered to express neoantigen-specific T-cell receptors (TCRs). Developed by PACT Pharma, the therapy utilizes a proprietary platform to identify patient-specific neoantigens presented by Human Leukocyte Antigen (HLA) molecules on the surface of tumor cells. Once identified, the corresponding TCR sequences are used to engineer the patient's own T cells, which are then expanded and re-infused to target and eliminate the tumor. This approach aims to overcome the limitations of traditional TCR therapies by providing a truly personalized treatment tailored to the unique mutational profile of an individual's cancer. NeoTCR-P201 is primarily being investigated for the treatment of various solid tumors.
- Other names
- NeoTCR P201
02
Targets
pMHC (Peptide-MHC complex family)CD3 (T-cell surface glycoprotein CD3)
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