Nepisond

**Nepisond** is an Italian specialized very-low-calorie, protein-based enteral nutrition formula used within a short-course protein-sparing modified fast protocol for severe obesity. The formula uses milk whey protein plus free amino acids including arginine, ornithine-alpha-ketoglutarate, taurine, cysteine, tryptophan, hydroxyproline, and citrulline, with linseed oil, L-carnitine, coenzyme Q10, policosanols, fructooligosaccharides, and electrolyte supplementation. It is delivered continuously through a nasogastric tube for approximately 14 days to maintain protein intake while inducing nutritional ketosis and marked caloric restriction. In a 364-patient study, this approach was associated with short-term weight loss and improvements in glycemic, lipid, and blood-pressure measures, although hyperuricemia and transient aminotransferase elevations occurred. ([ncbi.nlm.nih.gov](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438151/))

Brand names

Nepisond