neriifolin

**Neriifolin** is a plant-derived cardenolide (cardiac glycoside) found in species such as Cerbera odollam and Thevetia neriifolia, structurally related to the digitalis class of cardiac glycosides[1][4]. It inhibits the Na+/K+-ATPase (sodium-potassium pump), leading to increased intracellular calcium, causing positive inotropic effects in cardiac tissue (cardiotonic action), and can induce cell apoptosis[3][4][6]. Preclinical studies have shown anti-cancer activity through apoptosis in breast, ovarian, colorectal, and skin cancer lines and neuroprotective effects in models of ischemic stroke[3][4][6]. Neriifolin is considered a toxin due to its ability to induce cardiac arrhythmia and death in high doses, similar to other cardiac glycosides[1][4].

Other names

17β-neriifolin17α-neriifolindigitoxigenin+thevetose14-hydroxy-5β-card-20(22)-enolide 3-(6-deoxy-3-O-methyl-α-L-glucopyranoside)3β-[(6-deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide17beta-neriifolinCard-20(22)-enolide, 3-[(6-deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-, (3β,5β)-