nerium oleander extract

Nerium oleander extract is a botanical extract derived from the leaves or flowers of the *Nerium oleander* plant, containing a complex profile of cardiac glycosides, most notably **oleandrin**, as well as odoroside H and neritaloside. Its primary mechanism of action is the inhibition of the **alpha-3 subunit of Na+/K+-ATPase**. This inhibition triggers downstream signaling changes that attenuate the **mTOR** pathway, including the inhibition of **Akt**, **p70S6K**, and **NF-κB**, and the suppression of **FGF-2** (basic fibroblast growth factor) export. These molecular effects result in potent anti-tumor activity, including the induction of apoptosis and inhibition of glycolysis in cancer cells, as well as antiviral and anti-inflammatory properties. Standardized extracts like **PBI-05204** have been evaluated in clinical trials for advanced solid tumors and pancreatic cancer, showing potential to bypass traditional drug resistance mechanisms such as ABC transporters.

Brand names

AnvirzelBreastin

Other names

NOENAE-8NAE8NAE 8oleander extractNerium oleander ethanolic flower extractNOEE