Drug intelligence / Profile preview

Nerve Calm

Development stage
Unknown
Lead developer
Hylands Naturals
Modality
Small Molecules
Administration
Oral
01

Overview

Nerve Calm is a non-specific brand name used for a variety of over-the-counter products, including homeopathic remedies, dietary supplements, and certain pharmaceutical combinations, all marketed for the relief of nervous tension, stress, and neuropathic discomfort. The most widely recognized version is Hyland's Nerve Calm, a homeopathic formulation containing a blend of biochemic phosphates (cell salts) such as Kali Phosphoricum and Magnesia Phosphorica, which are traditionally used in homeopathy to support nervous system health and address mineral imbalances. Other products under this name, such as those from Nerve Renew or Natural Vitality, are dietary supplements that typically feature herbal extracts like passionflower and valerian root or minerals like magnesium, which are intended to modulate the GABAergic system and reduce neuronal excitability. In some international markets, 'Nerve Calm' (or 'Nerv-Calm') also refers to a pharmaceutical combination of pregabalin and methylcobalamin used for treating neuropathic pain. Because of these diverse formulations, the product does not have a single defined mechanism of action but rather represents a category of nerve-soothing interventions ranging from alternative medicine to conventional pharmacological treatments.

Brand names
Hyland's Nerve CalmNerve Renew Nerve CalmNatural Vitality Nerve CalmNerv-CalmSBL Nerve Calm
02

Targets

GABA-B (Gamma-aminobutyric acid receptor type B)NMDAR (Glutamate receptor ionotropic, NMDA)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)

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