Nestorone Ring

The **Nestorone Ring** is a progestin-only contraceptive vaginal ring developed by the Population Council, designed for continuous use over 3 or 6 months to provide contraception for women of reproductive age, including those with high BMI or breastfeeding postpartum. It delivers **segesterone acetate (Nestorone or NES)**, a potent 19-norprogesterone derivative that is not orally active but highly effective via vaginal delivery, inhibiting ovulation without estrogenic side effects like increased VTE risk associated with ethinyl estradiol. Clinical trials, including Phase 2b studies by the NICHD network, are evaluating its safety, efficacy, and bleeding patterns, with advantages such as no refrigeration need, user control, minimized bone density impact, and rapid fertility return.

Brand names

Nestorone Ring