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NeuroDirect Ketamine
- Development stage
- Unknown
- Lead developer
- Psycheceutical
- Modality
- Small Molecules
- Administration
- Topical, Transdermal
01
Overview
NeuroDirect Ketamine is a patented topical formulation of ketamine developed by Psycheceutical Bioscience for the treatment of mental health disorders, primarily post-traumatic stress disorder (PTSD). Unlike traditional systemic ketamine treatments, such as intravenous infusions or intranasal sprays, NeuroDirect is designed as a non-systemic cream applied to the back of the neck. This delivery method targets free nerve endings to provide rapid therapeutic effects—potentially within minutes—while bypassing the blood-brain barrier in a way that minimizes the hallucinogenic and dissociative side effects typically associated with systemic ketamine administration. The active ingredient, ketamine, acts as an NMDA receptor antagonist. The drug has completed a Phase 1 single-ascending-dose clinical trial in healthy volunteers to evaluate safety, tolerability, and pharmacokinetics, with further development planned for PTSD and other neuropsychiatric conditions.
- Brand names
- NeuroDirectNeuroDirect Ketamine
- Other names
- topical ketamine
02
Targets
AMPAR (AMPA receptor)NMDAR (Glutamate receptor ionotropic, NMDA)NTRK2 (Tropomyosin-related kinase receptor type B)Mechanistic target of rapamycin complex 1
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