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neuroinduced mesenchymal stem cells + mesenchymal stem cell-derived exosomes
- Development stage
- Unknown
- Lead developer
- Biocells Medical
- Modality
- Stem Cell Therapies → Cell Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Intranasal, Intrathecal
01
Overview
This investigational combination therapy, developed by Biocells Medical, consists of neuroinduced mesenchymal stem cells (MSCs) and purified MSC-derived exosomes. It is currently being evaluated in Phase I/II clinical trials for the treatment of spinocerebellar ataxia (also referred to in study titles as spinocerebellar palsy). The treatment protocol involves the administration of 200 million neuroinduced MSCs via intravenous or intrathecal infusion, complemented by the intranasal delivery of purified exosomes. This dual approach aims to leverage the regenerative potential of stem cells and the targeted delivery of neuroprotective paracrine factors via exosomes to mitigate neurodegeneration and improve motor function in patients with ataxia.
- Other names
- mesenchymal stem cell-derived exosomesneuroinduced mesenchymal stem cellsMSC-derived exosomes
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