Drug intelligence / Profile preview

neuronox

Development stage
Phase 4
Lead developer
Medytox
Modality
Recombinant Proteins and Enzymes
Administration
Intramuscular, Intradermal, Intradetrusor
01

Overview

Neuronox is a purified botulinum toxin type A product developed and manufactured by Medytox, a South Korean biopharmaceutical company. It is indicated for the treatment of benign essential blepharospasm in adults and is widely used in both therapeutic and cosmetic settings to manage conditions such as spasticity (including spastic equinus gait in cerebral palsy), muscle stiffness (in elbow, wrist, fingers, ankle and toe muscles), cervical dystonia, overactive bladder symptoms, chronic migraine prevention, hyperhidrosis (excessive sweating), strabismus (squint), and reduction of facial wrinkles[1][3][4][5][6][8][9]. Neuronox works by blocking the release of acetylcholine at neuromuscular junctions through cleavage of SNARE proteins—specifically SNAP-25—resulting in temporary muscle paralysis or relaxation[7][9]. The onset of action typically occurs within 2–4 days with effects lasting up to 6–7 months depending on indication and patient characteristics[8][9]. Clinical studies have shown Neuronox to be non-inferior to other established botulinum toxin products such as Botox for efficacy and safety[4].

Brand names
NeuronoxBotuliftSiaxCunox
Other names
botulinum toxin type AonabotulinumtoxinA
02

Targets

SNAP25 (Synaptosome-associated protein 25)SV2A (Synaptic vesicle glycoprotein 2A)Muscle-type nicotinic acetylcholine receptorVAMP (SNARE Protein Complex)

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