neuropeptide serum

The neuropeptide serum (specifically identified as **SkinCeuticals P-TIOX**) is a topical cosmeceutical formulation designed to address both dynamic and static facial wrinkles. Its primary active ingredients include a blend of neuropeptides: **acetyl hexapeptide-8** (Argireline), which inhibits the SNARE complex to reduce acetylcholine release, and **dipeptide diaminobutyroyl benzylamide diacetate** (Syn-Ake), an antagonist of the muscular nicotinic acetylcholine receptor. Together, these peptides work to relax facial muscles and reduce the appearance of expression lines. The serum also contains **polyhydroxy acids (PHA)** for gentle exfoliation, **niacinamide** for skin barrier support, and **laminaria extract**. Clinical data presented at the AAD 2026 meeting demonstrated that twice-daily application significantly improves forehead wrinkles, crow's feet, and overall skin radiance in male subjects over an 8-week period.

Brand names

P-TIOXSkinCeuticals P-TIOX

Other names

topical neuropeptide serum