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neutral-15d-PMJ2

Development stage: Unknown
Lead developer: East Carolina University
Modality: Small Molecules
Administration: Intraperitoneal

Overview

neutral-15d-PMJ2 is a synthetic, non-electrophilic analog of the endocannabinoid metabolite 15-deoxy-Δ12,14-prostamide J2 (15d-PMJ2). Developed by researchers at East Carolina University, it serves as a critical research tool for investigating the structure-activity relationship of prostamides in cancer models. The compound is structurally identical to 15d-PMJ2 except for the absence of the electrophilic double bond within its cyclopentenone ring. Research in B16F10 murine melanoma cells has shown that while 15d-PMJ2 induces apoptosis through endoplasmic reticulum (ER) stress and mitochondrial calcium mobilization, neutral-15d-PMJ2 fails to elicit these effects, thereby confirming that the electrophilic moiety is the essential structural component required for the biological activity of the parent molecule.

Other names: neutral 15-deoxy-Δ12,14-prostamide J2

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