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NEVAMAST® CREMA is a topical medical device developed by Epitech Group SpA for the symptomatic treatment of swelling, fatigue, and pain in the lower limbs associated with chronic venous insufficiency (CVI), microcirculatory disorders, and podological conditions. It utilizes the ALIAmide (Autacoid Local Injury Antagonism) mechanism, which involves the modulation of mast cells and other non-neuronal immune cells to control neuroinflammation and tissue reactivity. The product is classified as a Class C Medical Device in Italy and is part of a broader product family that includes oral and gel formulations. The cream is intended for twice-daily topical application to the affected areas of the foot, ankle, and leg.
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